Study on Angiographic Findings of Patients Received Different Thrombolytics

Abstract

Introduction Treatment for acute myocardial infarction (AMI), which can be fatal, often involves thrombolytic therapy (TLT). Nevertheless, there are a number of reasons why thrombolysis does not always work. Our goal was to evaluate and contrast the coronary angiographic profiles of individuals who had undergone successful and unsuccessful thrombolysis. Objective: To determine the result angiographic findings of patients who underwent different thrombolytics. Materials and Methods: This prospective study was conducted with ST-Segment Elevated ACS patients who underwent failed thrombolysis at Department of Cardiology, Northeast Medical College, Sylhet, from January 2021 to December 2021. Ethical committee approval and informed consent were obtained from all 120 participants. Patients with acute myocardial infarction were diagnosed based on electrocardiographic evidence. Patients were categorised into successful thrombolysis if there was > 50% ST-segment resolution within 60 minutes post-thrombolysis, coupled with chest pain resolution. Failed thrombolysis included patients with a < 50% ST-segment resolution or persistent chest pain were included in this study. Results: In comparison to older age groups, younger age groups demonstrated significantly greater success with failed thrombolytics (p<0.05). Relationship between successful and unsuccessful thrombolytics and the ejection fraction. Fifty-five percent of ejection fractions were significantly more successful than unsuccessful thrombolytics (p<0.05). Type B (59%), type A (25%), and type C (16%) lesions were the most common types with unsuccessful thrombolysis. Conclusion: There was a higher frequency of effective thrombolysis than failure thrombolysis. In resource-constrained scenarios where rapid mechanical reperfusion for STEMI is not feasible, the utility of thrombolysis is reinforced. Failed thrombolysis has been linked to diabetes, anterior wall MI (LAD region), and a Type B coronary artery lesion.