Relationship of Plasma Eosinophil Count with Coronary Artery Disease

Abstract

Background: Chronic inflammatory disorders that can have systemic effects include allergic asthma and atherosclerosis, a condition in which plaque buildup narrows arteries and increases the risk of coronary artery disease (CAD). Eosinophils (EOS) are inflammatory innate immune cells involved in arterial thrombogenesis. Objective: To investigate the connection between plasma eosinophil count and coronary artery disease. Materials and Methods: The case control study was conducted Department of cardiology, TMSS Medical College Hospital, total of 140 patients who underwent coronary angiography were recruited during March 2024 to February 2025. The study case group included 70 patients with isolated CAD and 70 control group consisted of age- and gender-matched subjects with normal coronary angiograms.  Results: Significantly higher were found Creatinin and Total cholesterol 0.75±0.1 and 211±45 in cases in comparison to 0.72±0.2 and 181±36 in controlled respectively (p <0.001). Eosinophils, neutrophils, lymphocytes, NLR and MPV (fL) were significantly investigated (p<0.05) comparison with cases and controlled. Gensini scores 32.75 ± 6.94 were in cases and 7.35 ±4.37 were in control (p <0.001). Smoking, ST-segment-elevation myocardial infarction (STEMI), and emergency PCI significantly differed from EOS after ≥0.03×109/L and EOS post <0.03×109/L (p <0.05). Neutrophils, lymphocytes, and NLR were substantially different between EOS post ≥0.03×109/L and EOS post <0.03×109/L (p < 0.05). Conclusion: Patients with coronary artery disease had significantly higher creatinine and cholesterol profiles, as well as a clinical and pathological relationship with decreased Eosinophils (EOS).